NOW Foods Glutathione 500mg
100 Vegan Capsules · Reduced Active Form · With Milk Thistle Extract & Alpha Lipoic Acid · Non-GMO · Vegan · Kosher · GMP Facility
- ✓Enhanced formula — 3 active ingredients in one capsule: 500mg Glutathione + 100mg Milk Thistle Extract + 50mg Alpha Lipoic Acid.
- ✓Free radical neutralizer — reduced active form of glutathione plus two synergistic antioxidants that support its effectiveness.
- ✓Vegan, Kosher, allergen-free — no wheat, gluten, soy, milk, egg, fish, shellfish, tree nut, or sesame. Safe for virtually all dietary needs.
- ✓NOW Foods — 50+ year family-owned company — one of the most trusted supplement brands in the USA.
- ✓4.7 stars from 954 verified reviews — Amazon's Overall Pick in the glutathione category.
🔒 Secure Amazon checkout • Vegan & Kosher • GMP Certified
NOW Foods Glutathione 500mg — Full Review
NOW Foods Glutathione 500mg stands out from other direct glutathione supplements because it doesn't stop at just glutathione. Each vegan capsule delivers 500mg of reduced-form L-Glutathione alongside 100mg of Milk Thistle Extract (standardized to 80mg Silymarin Flavonoids) and 50mg of Alpha Lipoic Acid — two well-researched compounds that work synergistically with glutathione for antioxidant and detoxification support.
NOW Foods has been a family-owned company for over 50 years and is one of the most respected names in the supplement industry. Their commitment to quality — GMP-certified manufacturing, third-party testing, and rigorous allergen controls — gives this product a credibility edge over many lower-tier brands at similar price points.
Why the Added Milk Thistle & Alpha Lipoic Acid Matter
Milk Thistle (Silymarin) is one of the most studied liver-supportive compounds in herbal medicine. It supports liver cell regeneration and has been shown to help maintain glutathione levels in liver tissue specifically. Alpha Lipoic Acid (ALA) is a universal antioxidant that can regenerate oxidized glutathione back to its active reduced form — essentially helping your body recycle the glutathione it produces. Together these additions make NOW's formula more than just direct supplementation.
At $37.90 for 100 capsules ($0.38/serving), NOW Glutathione is priced higher per serving than Nutricost but still significantly below the Immunocal-family products. For those who want the direct glutathione approach with meaningful synergistic support, this is the most well-rounded option in that category.
The capsule is designed for adults and should be taken once daily, preferably on an empty stomach for best absorption. It is vegan, Kosher, and manufactured without wheat, gluten, soy, milk, egg, fish, shellfish, tree nut, or sesame — making it one of the most broadly accessible supplements on this list.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
What's Inside — 3 Active Ingredients
NOW's formula goes beyond plain glutathione with two evidence-backed additions that support and extend its antioxidant activity:
L-Glutathione (Reduced Form)
500mg — Free Radical NeutralizerThe reduced (active) form of glutathione — the bioavailable version your body can use directly. At 500mg per capsule, this is a full therapeutic-strength dose. Glutathione is critical for healthy immune system function, proper detoxification processes, and directly neutralizing free radicals. It also maintains the activity of vitamins C and E.
Milk Thistle Extract
100mg — Standardized to 80mg SilymarinSilybum marianum (Fruit/Seeds) standardized to 80mg Silymarin Flavonoids (equivalent 80%). Milk Thistle is the most clinically studied liver-supportive botanical. Silymarin supports liver cell regeneration, helps maintain hepatic glutathione levels, and provides additional antioxidant protection. The liver is where most of your body's glutathione is produced and stored.
Alpha Lipoic Acid
50mg — Universal AntioxidantALA is unique among antioxidants because it works in both water-soluble and fat-soluble environments throughout the body. Most importantly for this formula, ALA helps regenerate oxidized glutathione (GSSG) back to its active reduced form (GSH) — essentially acting as a recycling agent that extends the functional life of every glutathione molecule in the formula.
Supplement Facts
* Daily Value (DV) not established.
Other Ingredients: Hypromellose (cellulose capsule), Microcrystalline Cellulose, Magnesium Stearate (vegetable source), Silicon Dioxide. Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients.
Why NOW Foods Stands Out
In a market full of pop-up supplement brands, NOW Foods is one of the few that has genuinely earned long-term consumer trust. Founded in 1968, the company has over 50 years of manufacturing experience and is a consistent leader in the natural supplement space.
Non-GMO
No genetically modified organisms in any ingredient.
Vegan & Vegetarian
100% plant-based capsule and ingredients — no animal products.
Kosher Certified
Certified Kosher — meets strict religious dietary standards.
GMP Facility
Manufactured in a Good Manufacturing Practice certified facility in the USA.
Made and Quality Tested in the USA
Unlike many supplement brands that outsource manufacturing, NOW Foods produces its supplements in its own GMP-certified facilities. The company was family-owned and operated for over 50 years and has built a reputation for consistent quality, transparent labeling, and fair pricing — rare qualities in the supplement industry.
NOW Glutathione — Pros & Cons
✔ What We Like
- Enhanced 3-in-1 formula — Glutathione + Milk Thistle + ALA
- Milk Thistle supports liver glutathione specifically
- Alpha Lipoic Acid helps recycle and extend glutathione activity
- Vegan, Kosher, and free from 9 major allergens
- 4.7 stars from 954 verified Amazon reviews
- Amazon Overall Pick in the glutathione category
- NOW Foods — 50+ year trusted family brand
- GMP-certified US manufacturing facility
- Best formula depth among direct GSH supplements on this list
✗ Worth Noting
- Higher cost per serving than Nutricost ($0.38 vs $0.17)
- Only 100 capsules vs Nutricost's 240
- Direct oral glutathione still faces absorption limitations
- No clinical patents or published studies on this specific product
- Best taken on empty stomach — requires some routine adjustment
How Does NOW Compare to the Other Options?
vs. Nutricost: NOW costs more per serving ($0.38 vs $0.17) and has fewer capsules, but the formula is meaningfully better — the Milk Thistle and ALA additions are clinically relevant, not just marketing. If you want the best direct-GSH formula, NOW wins on ingredient depth.
vs. Immunocal: Immunocal's precursor approach is still clinically superior for raising intracellular glutathione levels and is backed by 79 patents and 85 studies. NOW's direct supplementation approach is simpler and more affordable, but the absorption limitation applies here just as it does with Nutricost.
Best fit for: People who want a trusted, enhanced direct glutathione formula with additional liver and antioxidant support, at a mid-range price point, with full vegan and allergen-free credentials.
The Best Enhanced Direct Glutathione Formula
NOW Foods Glutathione 500mg is the most complete direct glutathione supplement on our list. The addition of clinically relevant doses of Milk Thistle Extract and Alpha Lipoic Acid makes this meaningfully more than just a glutathione capsule — these additions support liver-specific glutathione production and help recycle the molecule for extended antioxidant activity. Combined with NOW Foods' 50-year brand reputation, GMP manufacturing, and vegan/allergen-free credentials, this earns its Amazon Overall Pick status. The tradeoff is cost — it's pricier than Nutricost. For maximum intracellular impact backed by clinical research, Immunocal remains our #1.
Buy NOW Glutathione on Amazon →What Verified Buyers Are Saying
Another one of those must haves for people that care about taking care of their bodies. I take it usually first thing in the morning with a glass of humic minerals. This is a great free radical neutralizer at an affordable price. Now makes great supplements and I highly suggest their products.
I've been taking these for around a month now with no stomach irritation. I really like this brand of supplements because they are third party tested and tend to be cheaper than others. You have to take them on an empty stomach for the best absorption — I didn't know this at first so I thought I'd include that!
Helps make your skin soft and smooth!
Excellent product.
I started with a few milligrams but I'm going to order more. (Started small, increasing dose.)
Very good pills. (Translated from Spanish — reviewer noted very positive experience with product quality.)